Mourinho wants answers from authorities over the pile of games his side could face in September alone.
Spurs could end up playing seven matches in the space of just over two weeks. They are active in the Premier League, Carabao Cup and Europa League this month.
Should Tottenham beat Lokomotiv Plovdiv in the second round of Europa League qualifying next Thursday, they could play seven games between the 19th and 26th of September.
The start of a tough September starts against Everton on Sunday and Mourinho isn’t looking forward to it all.
He told talkSPORT: “If I think too much about it, I don’t know how to answer and I will get depressed. I don’t want to get depressed.”
“I want to go into every match with a smile, I want to go into every match positive.”
“But the other day, I made a challenge with my boys and I asked them which one of them thinks he can play all these nine matches for 90 minutes and nobody told me, ‘I can’.”
“So we all are very, very aware that it’s impossible to do it. It’s not human.”
Mourinho added: “It’s a big risk in terms of our ambitions.”
“First of all, because it’s very, very possible that you lose one of these matches, but in the Premier League you can lose and stay in competition.
“If you lose in the Europa League or Carabao Cup, you go out. So looking at that level, it’s a big risk. Injury – if everybody speaks about lots of matches in some periods, this is something unique, it never happens.”
